Diethylamine → ethyl 5-(N,N-diethylaminomethyl)-2-furoate

HRID 1701800

반응식

HRID 1701800 반응식
Cl[CH2:2][C:3]1[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1.[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C1C=CC=CC=1>[CH2:13]([N:15]([CH2:2][C:3]1[O:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1)[CH2:16][CH3:17])[CH3:14]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 263166Ethyl 5-(chloromethyl)-2-furancarboxylate

생성물 1

HCID 20346154ethyl 5-(N,N-diethylaminomethyl)-2-furoate

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Ethyl 5-(chloromethyl)-2-furoate (0.1 mole) is refluxed with diethylamine (0.25 mole) in 40 ml of benzene for one hour. The benzene solution is filtered off and washed with water. The organic layer is separated and dried over magnesium sulfate. The magnesium sulfate is removed by filtration and the organics are evaporated to dryness. The residue is distilled to give a pure fraction of ethyl 5-(N,N-diethylaminomethyl)-2-furoate boiling at 97°-106° C. at 0.1 mm of Hg.

후처리

  1. filtrationThe benzene solution is filtered off
  2. washwashed with water
  3. customThe organic layer is separated
  4. dry with materialdried over magnesium sulfate
  5. customThe magnesium sulfate is removed by filtration
  6. customthe organics are evaporated to dryness
  7. distillationThe residue is distilled

출처 및 근거

ORD 기록
ord-3dc60f99f2a140ba89ca3e4738118d19
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04195023

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