Potassium Carbonate → 2-(2-Chlorophenyl)bicyclopropyl

HRID 17021노트

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HRID 17021 반응식
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]1NN=[C:16]([CH:19]2[CH2:21][CH2:20]2)[CH2:15]1>C(O)CO>[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]1[CH2:15][CH:16]1[CH:19]1[CH2:21][CH2:20]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 593438925-(2-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole

생성물 1

HCID 673713862-(2-Chlorophenyl)bicyclopropyl수율 89.8%

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

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온도
100 °C

실험 절차

To a solution of 50 g (0.36 mol) of potassium carbonate in 600 g of ethylene glycol there are added at 190° C., in the course of 2 hours, 201.5 g of 5-(2-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole, prepared as described under A2. Stirring is then carried out for 2 hours at 190° C. The end of the reaction is indicated by cessation of the evolution of gas. The reaction mixture is then cooled to 100° C., whereupon phase separation occurs and the upper, product phase is separated off. 158 g of 2-(2-chlorophenyl)bicyclopropyl are obtained as crude product, which may be further purified, for example by distillation.

후처리

  1. customprepared
  2. customthe upper, product phase is separated off

출처 및 근거

ORD 기록
ord-b4ca4be6029f49a1af47e8574d8f9927
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737301B2

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