2-Naphthol → HCID 178479471, 화합물

HRID 1702607

반응식

HRID 1702607 반응식
[ClH:1].[NH:2]([CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([OH:15])=[O:14])[CH2:9][CH2:8]1)[C:3]([NH2:5])=[NH:4].[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1O.C1(N=C=NC2CCCCC2)CCCCC1>N1C=CC=CC=1>[ClH:1].[NH:2]([CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([O:15][C:18]2[CH:17]=[CH:16][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=2)=[O:14])[CH2:9][CH2:8]1)[C:3]([NH2:5])=[NH:4]

참가 물질

5

반응물 3

HCID 86632-NaphtholHCID 10868DicyclohexylcarbodiimideHCID 178479474HCID 178479474, 화합물

생성물 1

HCID 178479471HCID 178479471, 화합물수율 67.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A suspension of trans-4-guanidinomethylcyclohexanecarboxylic acid hydrochloride (47.1 g), β-naphthol (28.8 g) and dicyclohexylcarbodiimide (45.4 g) in pyridine (400 ml) was stirred at room temperature for 24 hours. After evaporation of solvent, to the residue was added water (500 ml), and the mixture was acidified with hydrochloric acid. The resulting white crystals were dissolved in methanol (500 ml). After evaporation of methanol, the residue was recrystallized from methanol to give β-naphtyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride (49.1 g, 67.8%), m.p. 195°-202° C.

후처리

  1. customAfter evaporation of solvent
  2. additionto the residue was added water (500 ml)
  3. dissolutionThe resulting white crystals were dissolved in methanol (500 ml)
  4. customAfter evaporation of methanol
  5. customthe residue was recrystallized from methanol

출처 및 근거

ORD 기록
ord-f9738bda71e149f6b074ac9ff2555b49
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04348410

연결된 노트

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