Timonacic → 3-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

HRID 1702702

반응식

HRID 1702702 반응식
[CH2:1]([NH:17][C:18]1[CH:37]=[CH:36][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([O:33]CC)=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([OH:33])=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:36][CH:37]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 9934TimonacicHCID 544239453-[4-(Hexadecylamino)cinnamoyl]-4-carboethoxy thiazolidine

생성물 1

HCID 538485433-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

시약·촉매·용매 1

HCID 86737261Acetone sodium bicarbonate용매

실험 절차

By means of the alkaline hydrolysis method of Example 54, the ethyl ester of Example 51 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 51 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

후처리

  1. customBy means of the alkaline hydrolysis method of Example 54
  2. customThis acid is also prepared

출처 및 근거

ORD 기록
ord-3276e6d51ce04e0f984c16c2e5bea113
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04348399

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