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Methane → N,N'-Bis(2-propenyl)carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride

HRID 1702840
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HRID 1702840 반응식
[Cl:1][C:2]1[C:11]([CH3:12])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.CO.C.[CH2:16]([NH:19][C:20]([NH:22][CH2:23][CH:24]=[CH2:25])=[S:21])[CH:17]=[CH2:18]>CC(C)=O>[ClH:1].[CH3:12][C:11]1[C:2]([S:21][C:20](=[N:19][CH2:16][CH:17]=[CH2:18])[NH:22][CH2:23][CH:24]=[CH2:25])=[N:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2
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참가 물질

6

반응물 4

HCID 297MethaneHCID 887Methanol2회HCID 2362762-Chloro-3-methylquinoxalineHCID 3034186Thiourea, N,N'-di-2-propen-1-yl-

생성물 1

HCID 131712831N,N'-Bis(2-propenyl)carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride수율 61.5%

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

2-Chloro-3-methylquinoxaline (3.56 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.125 g. (0.02 mole) of 1,3-diallylthiourea in 50 ml. of methanol. The mixture was stirred at room temperature for 31/2 hours, then freed of solvent. Acetone was added to the residue and the solution again freed of solvent. The residue was triturated with ether and with acetone, filtered, washed and dried to give 4.12 g. (61.5% yield), m.p. 90°-93° C.

후처리

  1. filtrationfiltered
  2. additionThe filtrate was added to 3.125 g
  3. customThe residue was triturated with ether and with acetone
  4. filtrationfiltered
  5. washwashed
  6. customdried
  7. customto give 4.12 g

출처 및 근거

ORD 기록
ord-d4d809f5afe249688c60105838fe0964
출처 데이터셋
uspto-grants-1982_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04349674

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