Ethyl 7-chloroheptanoate → 7-[3-(4-Chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] enanthic acid ethyl ester

HRID 1702881

반응식

HRID 1702881 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:11][NH:10][C:9]2=[O:19])=[CH:4][CH:3]=1.[CH2:20]([O:22][C:23](=[O:31])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]Cl)[CH3:21]>CN(C=O)C>[CH2:20]([O:22][C:23](=[O:31])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][N:10]1[CH:11]=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[C:9]1=[O:19])[CH3:21]

참가 물질

4

반응물 2

HCID 529988Ethyl 7-chloroheptanoateHCID 124189881-(4-Chlorophenyl)-5-phenyl-4-imidazolin-2-one

생성물 1

HCID 536577017-[3-(4-Chlorophenyl)-2-oxo-4-phenyl-4-imidazolin-1-yl] enanthic acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The product is obtained as described in example 1 from 1.35 g NaJ (80% suspension in mineral oil), 12.2 g of 1-(4-chlorophenyl)-5-phenyl-4-imidazolin-2-one, 100 cc. of DMF, 8.7 g of 7-chloroenanthic acid ethyl ester and 1.35 g of NaJ. Eluant in chromatographic purification: hexane/ethyl acetate.

후처리

  1. customThe product is obtained
  2. customEluant in chromatographic purification

출처 및 근거

ORD 기록
ord-70babe5b36c84ee19e60180bfe43ff58
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04349684

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