Acetyl chloride → Succinate

HRID 1702964

반응식

CC1[C@@H]2C[C@H]3[O:20][C:18](=[O:19])[C@H:17](O)[C@@H:16]4[C@@]53C[O:22][C@:15]4([C:24]([O:26]C)=[O:25])[C@@H:14]([OH:28])[C@H:13](O)[C@@H]5[C@@]2(C)CC(=O)C=1O.CC1[C@@H]2C[C@H]3[O:51][C:49](=[O:50])[C@H:48](OC(C=C(C)C)=O)[C@@H:47]4[C@@]53CO[C@@:46]4([C:61]([O:63]C)=[O:62])[C@@H](O)[C@H](O)[C@@H]5[C@@]2(C)CC(=[O:36])C=1O.C(Cl)(=O)CCC(Cl)=O.C(Cl)(=O)CCCC(Cl)=O.[C:86](Cl)(=[O:88])[CH3:87]>>[C:18]([O-:20])(=[O:19])[CH2:17][CH2:16][C:15]([O-:22])=[O:36].[C:61]([O-:63])(=[O:62])[CH2:46][CH2:47][CH2:48][C:49]([O-:51])=[O:50].[CH3:87][C:86]([CH2:13][C:14]([CH2:15][C:24]([OH:26])=[O:25])=[O:28])=[O:88]

참가 물질

반응물 5

HCID 6367Acetyl chloride

HCID 10970Succinyl chloride

HCID 17887Pentanedioyl dichloride

HCID 99531Bruceolide

HCID 12302104HCID 12302104, 화합물

생성물 3

HCID 160419Succinate

HCID 4418048Glutarate(2-)

HCID 54598443,5-Dioxohexanoic acid

실험 절차

In accordance with the above procedure, but where, in place of 3,4-dimethyl-2-pentenoyl chloride, there is utilized benzoyl chloride, trimethoxybenzoyl chloride or cinnamoyl chloride there is obtained the corresponding 3-ester or 3,15-diester. Similarly, but where, in place of bruceolide, there is utilized brusatol and as an acid chloride there is utilized succinoyl chloride, glutaroyl chloride and acetyl chloride, there is obtained 3,3-bisbrusatolyl succinate, 3,3-bisbrusatolyl glutarate and 3,11,12-brusatolyl triacetate, 3, 11, 12 bis brusatolyl triacetate can also be prepared by acetylation with pyridine in acetic anhydride.

출처 및 근거

ORD 기록: ord-233cfa63431c469c810679ed744ad36f
출처 데이터셋: uspto-grants-1982_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04350638

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