4(3H)-Quinazolinone, 3-amino-2-hydrazino- → 3-amino-2-(4-hydroxybutylamino)-quinazolin-4(3H)-one
반응식
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[NH:13]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[NH:13][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]참가 물질
3
실험 절차
16 g of 3-amino-2-hydrazinoquinazolin-4(3H)-one were stirred in 48 ml of 4-aminobutanol at 160° C. for 3 days and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water and the mixture was seeded and stored at 0° C. overnight to crystallize the product. The mixture was filtered and the recovered product was washed and dried to obtain 12.05 g of 3-amino-2-(4-hydroxybutylamino)-quinazolin-4(3H)-one.
후처리
- distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
- additionThe residue was diluted with water
- customto crystallize the product
- filtrationThe mixture was filtered
- washthe recovered product was washed
- customdried
출처 및 근거
- ORD 기록
- ord-07af5b9f35ab44a8b67e8e3dfb7b95c0
- 출처 데이터셋
- uspto-grants-1982_09
- 특허 번호
- US04350695
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