HCID 20497519, 화합물 → HCID 20524256, 화합물

HRID 1702981노트

반응식

HRID 1702981 반응식
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

참가 물질

3

반응물 1

HCID 20497519HCID 20497519, 화합물

생성물 1

HCID 20524256HCID 20524256, 화합물수율 126.7%

시약·촉매·용매 1

HCID 258684-Amino-1-butanol용매

실험 절차

20 g of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one were stirred in 100 ml of 4-aminobutanol at 175° C. for 24 hours and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water to crystallize out the product and the mixture was filtered. The product was washed and dried to obtain 16.2 g of 3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one.

후처리

  1. distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
  2. additionThe residue was diluted with water
  3. customto crystallize out the product
  4. filtrationthe mixture was filtered
  5. washThe product was washed
  6. customdried

출처 및 근거

ORD 기록
ord-e28a6e4f926c42078dcb238f07dd8c7b
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350695

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