Borane → 4-(Thiophen-2-yl)butan-1-ol

HRID 1703097노트

반응식

HRID 1703097 반응식
B.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][C:10](O)=[O:11]>O1CCCC1>[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]

참가 물질

4

반응물 2

HCID 6331BoraneHCID 783864-(2-Thienyl)Butyric Acid

생성물 1

HCID 126238624-(Thiophen-2-yl)butan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 240 ml. of 1 M borane in tetrahydrofuran chilled in an ice bath, is added dropwise, 20.4 g. of 4-(2-thienyl)butyric acid in 50 ml. of tetrahydrofuran. After the addition, the mixture is allowed to stand at room temperature for 17 hours and is poured onto ice. After standing, the mixture is extracted with ether, the ether extract washed with water, dried over magnesium sulfate and concentrated in vacuo to give a pale yellow oil.

후처리

  1. additionis added dropwise
  2. additionAfter the addition
  3. additionis poured onto ice
  4. extractionthe mixture is extracted with ether
  5. extractionthe ether extract
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo
  9. customto give a pale yellow oil

출처 및 근거

ORD 기록
ord-1dafd2cf709549f5ba585d6b6c3b5e39
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350822

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