1-(2-Furoyl)piperazine → 2-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride

HRID 1703372노트

반응식

HRID 1703372 반응식
[Cl:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[O:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22]>C(O)CC(C)C>[ClH:1].[O:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([N:23]1[CH2:24][CH2:25][N:26]([C:2]2[N:11]=[C:10]([NH2:12])[C:9]3[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=3)[N:3]=2)[CH2:27][CH2:28]1)=[O:22]

참가 물질

4

반응물 2

HCID 5502061-(2-Furoyl)piperazineHCID 129200072,6-Dichloro-7-methoxyquinazolin-4-amine

생성물 1

HCID 205063992-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride수율 79%

시약·촉매·용매 1

HCID 31260Isoamyl Alcohol용매

실험 절차

The title compound was prepared similarly by refluxing 2,6-dichloro-4-amino-7-methoxyquinazoline and 1-(2-furoyl)piperazine in isoamyl alcohol, M.P. 229°-31° C., 79% yield.

출처 및 근거

ORD 기록
ord-d4c8bfcdf07847fb8a745973b0d442e3
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04351940

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