Acetic Acid → 2-Phenyl-1,2,4,5,6,7-hexahydro-indazol-3-one

HRID 1703436노트

반응식

HRID 1703436 반응식
[C:1]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=O)([O:3]C)=O.[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C1(C)C=CC=CC=1.C(O)(=O)C>O>[C:12]1([N:18]2[C:1](=[O:3])[C:5]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[NH:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 1140TolueneHCID 7516PhenylhydrazineHCID 170489Cyclohexanecarboxylic acid, 2-oxo-, methyl ester

생성물 1

HCID 31161752-Phenyl-1,2,4,5,6,7-hexahydro-indazol-3-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

32.9 Parts of a mixture containing 60% 2-carboethoxyclohexanone and 40% of 2-carbomethoxycyclohexanone purchased from Aldrich Chemical Company, Milwaukee, Wisconsin 53233, and 21.6 parts of phenylhydrazine purchased from Eastman Organic Chemicals Company, Rochester, N. Y. 14650, were admixed in 200 parts of toluene containing 2.0 parts of acetic acid. The mixture was refluxed for two hours with water removal. The resulting yellow suspension was cooled to 0°. The solid was collected, washed with hexane and dried. The yield was 37.1 parts of white solid with m.p. 178°-181°.

후처리

  1. addition32.9 Parts of a mixture containing 60% 2-carboethoxyclohexanone
  2. temperatureThe resulting yellow suspension was cooled to 0°
  3. customThe solid was collected
  4. washwashed with hexane
  5. customdried

출처 및 근거

ORD 기록
ord-be914280c2b748fa9054d9dd8b7a7b22
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04124373

반응 노트

불러오는 중…