4-Nitrophenol → Ethyl 2-(4-nitrophenoxy)tetradecanoate

HRID 1703449노트

반응식

HRID 1703449 반응식
[CH:1]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][CH:4]=[C:3]([OH:10])[CH:2]=1.[CH2:11]([O:13][C:14](=[O:29])[CH:15](Br)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12]>CC(C)=O>[CH2:11]([O:13][C:14](=[O:29])[CH:15]([O:10][C:3]1[CH:4]=[CH:5][C:6]([N+:7]([O-:9])=[O:8])=[CH:1][CH:2]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12]

참가 물질

4

반응물 2

HCID 9804-NitrophenolHCID 85791Tetradecanoic acid, 2-bromo-, ethyl ester

생성물 1

HCID 54095639Ethyl 2-(4-nitrophenoxy)tetradecanoate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

153 g (1.1 mol) of p-nitrophenol, 1.3 liters acetone and 336 g (1.0 mol) of ethyl-α-bromo-tetradecanoate were placed in a 5-liter 3-necked flask and heated on a steam bath with stirring, for 60 hours. The product was filtered to remove inorganic salt and then the acetone was distilled off under vacuo. The residual oil was taken up in hexane, filtered, and concentrated under vacuo. Yield of Intermediate I was 361 g. TLC Analysis (benzene) showed only one spot, indicating a single product.

후처리

  1. temperatureheated on a steam bath
  2. filtrationThe product was filtered
  3. customto remove inorganic salt
  4. distillationthe acetone was distilled off under vacuo
  5. filtrationfiltered
  6. concentrationconcentrated under vacuo

출처 및 근거

ORD 기록
ord-a514fbd097f841368793f2eca21dad84
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04124396

반응 노트

불러오는 중…