Dimethylformamide → 5-Cyanomethyl-2,7-dibromo-3-phenylbenzofuran

HRID 1703561

반응식

HRID 1703561 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]([Br:19])[C:6]2[O:10][C:9]([Br:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:7]=2[CH:18]=1.[CH3:20][N:21](C)C=O.[C-]#N.[Na+]>O>[C:20]([CH2:2][C:3]1[CH:4]=[C:5]([Br:19])[C:6]2[O:10][C:9]([Br:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:7]=2[CH:18]=1)#[N:21]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 213199325-Bromomethyl-2,7-dibromo-3-phenylbenzofuran

생성물 1

HCID 213199065-Cyanomethyl-2,7-dibromo-3-phenylbenzofuran

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 17.8 g. (0.040 mole) of 5-bromomethyl-2,7-dibromo-3-phenylbenzofuran in 150 ml. of N,N-dimethylformamide, 2.0 g. (0.04 mole) of sodium cyanide and 15 ml. of water is heated on a steam bath for 1.5 hours. The mixture is poured into one liter of water and stirred for about 16 hours. The mixture is extracted with 500 ml. of ethyl acetate, the extracts washed with water, then dried. Evaporation followed by trituration with hexane-ethyl acetate gives 5-cyanomethyl-2,7-dibromo-3-phenylbenzofuran as a white solid.

후처리

  1. extractionThe mixture is extracted with 500 ml
  2. washof ethyl acetate, the extracts washed with water
  3. customdried
  4. customEvaporation

출처 및 근거

ORD 기록
ord-2e59e37a6eea4b8e8122b05895f28d40
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04124704

연결된 노트

불러오는 중…