Ethanol → 5-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester

반응식

[CH3:1][N:2]1[C:6]([NH2:7])=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:4]=[N:3]1.[CH:13]([OH:16])(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:16][CH:13]=[N:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:18]

참가 물질

반응물 3

HCID 702Ethanol

HCID 271299Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

HCID 5231666Orthoformic acid

생성물 1

HCID 867361415-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester수율 87%

실험 절차

84.6 g. of 1-methyl-4-carboethoxy-5-aminopyrazole and 74.1 g. of orthoformic acid triethyul ester are heated together until the splitting off of ethanol has ended. The oily residue is distilled under oil pump vacuum to obtain 5-[(ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester b.p. 98°-102°; m.p. 32°-34° (yield87%).