Nitric Acid → 5-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

반응식

[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH2:10][OH:11].[N+]([O-])(O)=O>>[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH:10]=[O:11]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 12493277HCID 12493277, 화합물

생성물 1

HCID 124932825-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

실험 절차

An 80 gm. portion of 5-methyl-2-n-propyl-4-imidazolemethanol is oxidized with 67.3 ml. of concentrated HNO3. A second portion of 101.4 gm. of the above compound is oxidized with 77 ml. of the acid. The reaction mixtures are combined, neutralized and worked up as in Example 25, giving the desired product, m.p. 126°-129° C.

후처리

customThe reaction mixtures

출처 및 근거

ORD 기록: ord-119bffd7f1ac4d869fe4c2608d56b312
출처 데이터셋: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04124766

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