Acetaldehyde → 1-(4'-Trifluoromethyl-biphenyl-4-yl)-ethanol

HRID 1703786노트

반응식

HRID 1703786 반응식
[Mg].[F:2][C:3]([F:18])([F:17])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13](Br)=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[CH:19](=[O:21])[CH3:20]>O1CCCC1.BrBr>[F:2][C:3]([F:18])([F:17])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:19]([OH:21])[CH3:20])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1

참가 물질

6

반응물 3

HCID 177AcetaldehydeHCID 5462224MagnesiumHCID 127123494-Bromo-4'-(trifluoromethyl)biphenyl2회

생성물 1

HCID 227603321-(4'-Trifluoromethyl-biphenyl-4-yl)-ethanol

시약·촉매·용매 2

HCID 24408Bromine촉매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

To a stirred suspension of 1.5 g of magnesium turnings in 10 ml of dry tetrahydrofuran, add a small amount of 4'-trifluoromethyl-4-bromo[1,1']biphenyl and a few drops of bromine. When the reaction is started, add (dropwise) a solution of 16 g of 4'-trifluoromethyl-4-bromo-[1,1']biphenyl in 50 ml of tetrahydrofuran at 50°-60° C. Heat the mixture for one hour, cool to 0° C., and slowly (dropwise) add 7 g of acetaldehyde. Stir the reaction mixture at room temperature for twenty hours. Work-up the reaction mixture following the procedure of example 2, and isolate the desired product by chromatography, m.p. 116°-117°.

후처리

  1. temperatureHeat the mixture for one hour

출처 및 근거

ORD 기록
ord-fa52e0b551834cedb292336b24ee4b2d
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125612

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