Bromo-4'-chloro-3'-sulfamoylacetophenone → 4-(4-Chloro-3-sulfamoylphenyl)-2-isobutylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

HRID 1703853

반응식

HRID 1703853 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][Br:10])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13].[CH2:16]([NH:20][C:21]([NH:23][CH3:24])=[S:22])[CH:17]([CH3:19])[CH3:18]>>[BrH:10].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:11])[CH2:9][S:22][C:21](=[N:20][CH2:16][CH:17]([CH3:19])[CH3:18])[N:23]2[CH3:24])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13]

참가 물질

3

반응물 2

HCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenoneHCID 155682431-Isobutyl-3-methylthiourea

생성물 1

HCID 227604724-(4-Chloro-3-sulfamoylphenyl)-2-isobutylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

실험 절차

6.2 g of 4'-chloro-3'-sulfamoyl-2-bromoacetophenone and 3.0 g of 1-isobutyl-3-methylthiourea were reacted according to the prescription made in Example 23 and the colorless end product was precipitated with 200 ml of diethyl ether. Decomposition beginning at 122° C., γC=N 1620 cm-1.

후처리

  1. customthe colorless end product was precipitated with 200 ml of diethyl ether
  2. custombeginning at 122° C.

출처 및 근거

ORD 기록
ord-17064eb4c0674623bb8e5a858bd720d7
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125614

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