N,N'-Dicyclopropylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 1703863노트

반응식

HRID 1703863 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:19][C:20]([NH:22][CH:23]2[CH2:25][CH2:24]2)=[S:21])[CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:21][C:20](=[N:19][CH:16]3[CH2:18][CH2:17]3)[N:22]2[CH:23]2[CH2:25][CH2:24]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

참가 물질

3

반응물 2

HCID 17750075N,N'-DicyclopropylthioureaHCID 213167492,4'-Dichloro-3'-sulfamoylacetophenone

생성물 1

HCID 227605674-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

실험 절차

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 3.1 g of 1,3-dicyclopropylthiourea were reacted according to the prescription given in Example 12 and the colorless crystalline precipitate of the end product was filtered off.

후처리

  1. filtrationthe colorless crystalline precipitate of the end product was filtered off

출처 및 근거

ORD 기록
ord-7690362a8793417196e056a245d8ffa9
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125614

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