Water → N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

HRID 1704009노트

반응식

HRID 1704009 반응식
S1CCS[C:2]21[C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]2.O.C(=O)([O-])[O-:19].[Ca+2]>C(#N)C>[O:19]=[C:2]1[C:10]2[S:11][CH:12]=[CH:13][C:9]=2[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]1

참가 물질

5

반응물 3

HCID 962WaterHCID 10112Calcium CarbonateHCID 86735494N-(5,6-dihydrospiro[benzo-[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide

생성물 1

HCID 23347790N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

To a stirred mixture of N-(5,6-dihydrospiro[benzo[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide (1.5 g), acetonitrile (20 ml) and water is added calcium carbonate (1.65 g) and mercuric chloride (3.0 g). The mixture is stirred at room temperature for 35 minutes and acetonitrile is added. The solid is filtered and washed with acetonitrile. The filtrate (100 ml) is evaporated to dryness to afford the title compound.

후처리

  1. filtrationThe solid is filtered
  2. washwashed with acetonitrile
  3. customThe filtrate (100 ml) is evaporated to dryness

출처 및 근거

ORD 기록
ord-5d904847e63740b9b37dd607a96e547d
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125539

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