rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride → cis-2-Cyclohexylcyclopentylamine hydrochloride

HRID 1704205

반응식

HRID 1704205 반응식
[ClH:1].[C:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>O>[ClH:1].[CH:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

참가 물질

4

반응물 2

HCID 70051154rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochlorideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 70050481cis-2-Cyclohexylcyclopentylamine hydrochloride수율 33.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Using rhodium-on-charcoal catalyst in a Paar shaker, 12.6 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 204°-206° C. in 100 ml of water was hydrogenated. In 20 hours when the theoretical amount of hydrogen had been taken up the catalyst was removed by filtration, the filtrate made basic with sodium hydroxide solution, and the resulting precipitate was extracted into ether. After evaporation of the ether the residue was distilled, B.P. 100°-102° C. (6.0 mm). The hydrochloride salt was prepared and recrystallized from isopropanolether to give 4.4 g of cis-2-(cyclohexyl)cyclopentylamine hydrochloride, M.P. 174°-176° C.

후처리

  1. customthe catalyst was removed by filtration
  2. extractionthe resulting precipitate was extracted into ether
  3. customAfter evaporation of the ether the residue
  4. distillationwas distilled
  5. customrecrystallized from isopropanolether

출처 및 근거

ORD 기록
ord-f5a734f083794ac9836bb8272275440a
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04126611

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