Ethyl 3-oxovalerate → Diethyl 2-Propionylazelate

HRID 1704356노트

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HRID 1704356 반응식
[C:1]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3].[CH2:11]([O:13][C:14]([CH:16](C(=O)C)[CH2:17][C:18]#[C:19][CH2:20][CH2:21]CC(OC)=O)=[O:15])[CH3:12].BrCCCCCCC(OCC)=O>>[C:1]([CH:5]([CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][C:14]([O:13][CH2:11][CH3:12])=[O:15])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3]

참가 물질

4

반응물 3

HCID 78656Ethyl 3-oxovalerateHCID 122490Ethyl 7-bromoheptanoateHCID 22759276Methyl 8-Ethoxycarbonyl-9-oxo-5-decynoate2회

생성물 1

HCID 22759291Diethyl 2-Propionylazelate

실험 절차

The synthesis of this compound is carried out by the procedure of Example 4, Step A, except that an equivalent quantity of ethyl propionylacetate is substituted for the ethyl acetoacetate of Example 4, Step A, and an equivalent quantity of ethyl 7-bromoheptanoate is substituted for the methyl 7-bromo-5-heptynoate of Example 4, Step A. The product, a viscous oil, is used in the next step directly without distillation.

후처리

  1. customThe synthesis of this compound
  2. distillationThe product, a viscous oil, is used in the next step directly without distillation

출처 및 근거

ORD 기록
ord-b40bd894bfd64ceba0582cf8f7b08c27
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04126629

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