2-Amino-4,6-dimethoxy-1,3,5-triazine → N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-chlorobenzenesulfonamide

HRID 1704612노트

반응식

HRID 1704612 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[S:19]([N:22]=[C:23]=[O:24])(=[O:21])=[O:20]>C(Cl)Cl>[CH3:9][O:8][C:6]1[N:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:23]([NH:22][S:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[Cl:12])(=[O:20])=[O:21])=[O:24])[N:7]=1

참가 물질

4

반응물 2

HCID 278402-Amino-4,6-dimethoxy-1,3,5-triazineHCID 174071Benzenesulfonyl isocyanate, 2-chloro-

생성물 1

HCID 14835175N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-chlorobenzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 15.6 g of 2-amino-4,6-dimethoxy-1,3,5-triazine in 300 ml of dry methylene chloride containing 0.1 g 1,4-diazabicyclo[2,2,2]octane was added 21 g 2-chlorobenzenesulfonyl isocyanate with stirring. The mixture was stirred for 16 hours and the resultant solid was removed by filtration. After washing the solid with 1-chlorobutane, the resulting product, N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)-aminocarbonyl]-2-chlorobenzenesulfonamide melted at 188°-189° C. Infrared absorption analysis showed absorption peaks at 1740 cm-1, 1630 cm-1 and 1595 cm-1 which are typical for this type of compound.

후처리

  1. stirringThe mixture was stirred for 16 hours
  2. customthe resultant solid was removed by filtration
  3. washAfter washing the solid with 1-chlorobutane
  4. customabsorption analysis
  5. customabsorption peaks at 1740 cm-1, 1630 cm-1 and 1595 cm-1 which

출처 및 근거

ORD 기록
ord-3f5511fb26d5403e9c89d6032cc99f9b
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127405

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