2-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl- → HCID 3050036, 화합물

HRID 1704731노트

반응식

HRID 1704731 반응식
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([CH3:19])=[O:18])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH:16]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]([OH:18])[CH3:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 30500342-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl-

생성물 1

HCID 3050036HCID 3050036, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

To 1-(N-2-phenoxy-ethyl-piperazino)-1-phenylacetone (1 mole) dissolved in anhydrous methanol (1 liter) is added BH4K (1 mole) portionwise, at 0° C., with stirring. On completion of the addition (1 hour), the reaction mixture is stirred 24 hours at room temperature. The methanol is removed in vacuo over a water-bath, the resulting material is then taken up into methylene chloride which is washed with water to neutral pH. Concentration gives white crystals which melt at 100° C.

후처리

  1. additionis added BH4K (1 mole) portionwise
  2. additionOn completion of the addition (1 hour)
  3. stirringthe reaction mixture is stirred 24 hours at room temperature
  4. customThe methanol is removed in vacuo over a water-bath
  5. washis washed with water to neutral pH
  6. concentrationConcentration
  7. customgives white crystals which
  8. custommelt at 100° C.

출처 및 근거

ORD 기록
ord-268962db1cb4492fb5cf2efe65386f95
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127661

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