Phenyl isocyanate → Pencycuron

HRID 1704751

반응식

HRID 1704751 반응식
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:10][C:11]1[CH:23]=[CH:22][C:14]([CH2:15][NH:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>CCCCCC>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][N:16]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 8340834-Chloro-N-cyclopentylbenzylamine

생성물 1

HCID 91692Pencycuron수율 95%

시약·촉매·용매 1

HCID 8058Hexane용매2회

실험 절차

A solution of 12 grams (0.1 mole) of phenylisocyanate in 50 ml of hexane was added dropwise to 21 grams (0.1 mole) of N-4-chlorobenzyl-N-cyclopentylamine in 400 ml of hexane under cooling and stirring conditions. After the addition, the temperature of the reaction mixture was gradually raised, and the solution was then stirred at 50° C. for about 7 hours. The mixture was cooled and filtered. The residue was recrystallized from a mixed solvent of hexane-ethyl alcohol. 31 grams of N-4-chlorobenzyl-N-cyclopentyl-N'-phenylurea were obtained. Yield: 95%. Melting point: 129°-134° C.

후처리

  1. temperatureunder cooling
  2. additionAfter the addition
  3. temperaturethe temperature of the reaction mixture was gradually raised
  4. stirringthe solution was then stirred at 50° C. for about 7 hours
  5. temperatureThe mixture was cooled
  6. filtrationfiltered
  7. customThe residue was recrystallized from a mixed solvent of hexane-ethyl alcohol

출처 및 근거

ORD 기록
ord-3135366f812149b0991e7679a9603783
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127673

연결된 노트

불러오는 중…