Ammonia → 7-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidine

HRID 1704779

반응식

HRID 1704779 반응식
[NH2:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1.N.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15]Cl>>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15][NH:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 95769(1,2,5)Thiadiazolo(3,4-d)pyrimidin-7-amineHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzene

생성물 1

HCID 204820257-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidine수율 25%

반응 조건

온도
110 °C

실험 절차

An autoclave was charged with 1.54 g. (0.01 mole) of 7-amino[1,2,5]thiadiazolo[3,4-d]pyrimidine prepared by the process set forth in Example 1, 5.1 g. (0.3 mole) ammonia and 4.48 g. (0.025 mole) 2-chloro-6-fluorobenzyl chloride. The vessel was sealed and the contents heated at 110° C. for 15 hours. After cooling and evaporation of the excess ammonia, the resulting solid was collected by filtration, washed successively with water and hexane to afford a 25% yield of product.

후처리

  1. additionAn autoclave was charged with 1.54 g
  2. customThe vessel was sealed
  3. temperatureAfter cooling
  4. customevaporation of the excess ammonia
  5. filtrationthe resulting solid was collected by filtration
  6. washwashed successively with water and hexane

출처 및 근거

ORD 기록
ord-640dc70040b54c33ad486aca2e13e8f2
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127721

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