Chloromethyl methyl sulfide → 2-methyl-4-methylthiomethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

HRID 1704840

반응식

HRID 1704840 반응식
[CH3:1][S:2][CH2:3]Cl.CN(CCCCl)C.[CH3:12][C:13]1[CH:29]=[C:16]2[NH:17][C:18](=[O:28])[C:19]3[CH:24]=[N:23][C:22]4[NH:25][N:26]=[CH:27][C:21]=4[C:20]=3[N:15]2[N:14]=1.C(N1C2N=CC3C(=O)NC4N(N=C(C)C=4)C=3C=2C=N1)C>>[CH3:12][C:13]1[CH:29]=[C:16]2[N:17]([CH2:3][S:2][CH3:1])[C:18](=[O:28])[C:19]3[CH:24]=[N:23][C:22]4[NH:25][N:26]=[CH:27][C:21]=4[C:20]=3[N:15]2[N:14]=1

참가 물질

5

반응물 4

HCID 16916Chloromethyl methyl sulfideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 1357053822-methyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-oneHCID 1358394108-ethyl-2-methyl-4-H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

생성물 1

HCID 227575022-methyl-4-methylthiomethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

실험 절차

By substituting methylthiomethyl chloride for the dimethylaminopropyl chloride in the procedure of Example 4 and substituting the 2-methyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one obtained in Example 8 for the 8-ethyl-2-methyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one, 2-methyl-4-methylthiomethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is obtained.

출처 및 근거

ORD 기록
ord-eadc86e83a5c44628ca42e64cb6524ac
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127657

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