Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → Fosmidomycin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Magnesium Hydroxide | HCID 73981 | — |
| 반응물 | 3-(Hydroxyamino)propylphosphonic acid | HCID 342170 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Fosmidomycin | HCID 572 | 65.8% |
반응 단계
An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04206156 |
| 출처 데이터셋 | uspto-grants-1980_06 |
| ORD ID | ord-d0d185827fa64e5797039853d4dfd715 |
| 출처 메모 | uspto-grants-1980_06 |