Formic Acid → Fosmidomycin

HRID 1706221

반응식

HRID 1706221 반응식
[OH:1][NH:2][CH2:3][CH2:4][CH2:5][P:6](=[O:9])([OH:8])[OH:7].[C:10](OC(=O)C)(=[O:12])C.C(O)=O.[OH-].[Mg+2].[OH-]>O>[CH:10]([N:2]([CH2:3][CH2:4][CH2:5][P:6](=[O:8])([OH:7])[OH:9])[OH:1])=[O:12]

참가 물질

6

반응물 4

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 73981Magnesium HydroxideHCID 3421703-(Hydroxyamino)propylphosphonic acid

생성물 1

HCID 572Fosmidomycin수율 65.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.

후처리

  1. temperaturecooling

출처 및 근거

ORD 기록
ord-d0d185827fa64e5797039853d4dfd715
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04206156

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