4-Aminobenzonitrile → 4-(1H-Pyrrol-1-yl)benzonitrile
반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.CO[CH:12]1[CH2:16][CH2:15][CH:14](OC)O1>C1(C)C=CC=CC=1>[N:1]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1참가 물질
4
실험 절차
A mixture of 4-aminobenzonitrile (50 g., 0.42 mole), 2,5-dimethoxytetrahydrofuran (56 g., 0.42 mole) and 4A molecular sieves (184 g) in toluene (560 ml) was heated under reflux for 24 hrs. The residue from evaporation was washed with pet. ether and then recrystallized from diisopropyl ether to yield 42.5 g (60%) of 4-(1-pyrrolyl)benzonitrile, m.p. 104°-106° C.
후처리
- temperaturewas heated
- temperatureunder reflux for 24 hrs
- customThe residue from evaporation
- washwas washed with pet. ether
- customrecrystallized from diisopropyl ether
출처 및 근거
- ORD 기록
- ord-fcc08d14595a44be8de04a162ee93a80
- 출처 데이터셋
- uspto-grants-1980_06
- 특허 번호
- US04207329
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