HCID 20333776, 화합물 → HCID 20333770, 화합물

HRID 1706614노트

반응식

HRID 1706614 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][CH2:10][CH2:9][N:8]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[C:6]=2[CH:19]=1.Cl[CH2:21][CH2:22][C:23]([N:25]=[C:26]=[S:27])=[O:24]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:26]3[S:27][CH2:21][CH2:22][C:23](=[O:24])[N:25]=3)[CH2:10][CH2:9][N:8]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[C:6]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 20333776HCID 20333776, 화합물HCID 21890227HCID 21890227, 화합물

생성물 1

HCID 20333770HCID 20333770, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 Parts of 7-chloro-5-(o-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine and 12 parts of 3-chloropropionylisothiocyanate is dissolved in 100 parts by volume of tetrahydrofuran and the resultant solution refluxed for about 18 hours. The reaction mixture is then cooled to ambient temperature and filtered. The solvent is removed from the filtrate and the residue crystallized from a mixture of methylene chloride and hexane to afford 7-chloro-5-(o-chlorophenyl)-2,3-dihydro-1-(5,6-dihydro-4-oxo-4H-1,3-thiazin-2-yl)-1H-1,4-benzodiazepine. This compound is represented by the following formula ##STR31##

후처리

  1. filtrationfiltered
  2. customThe solvent is removed from the filtrate
  3. customthe residue crystallized from a mixture of methylene chloride and hexane

출처 및 근거

ORD 기록
ord-f01d85e8fa8c4f9299a08618a01ee113
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04208327

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