3,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrate → 58579-77-4
반응식
C(O[C:4](=[O:16])[CH2:5][NH:6][CH2:7][C:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:15])C.[N+]([O-])(O)=O.C[C:22]1C=C(C)N(C(N)=N)[N:23]=1>C(O)C>[CH3:14][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:8]=1[CH2:7][N:6]1[CH2:5][C:4](=[O:16])[NH:23][C:22]1=[N:15]2참가 물질
4
실험 절차
A mixture of N-(2-amino-6-methylbenzyl)glycine ethyl ester (1.097 g, 0.0049 mole) and 3,5-dimethylpyrazole-1-carboxamidine nitrate (0.993 g, 0.0049 mole) in absolute ethanol (15 ml) was heated at reflux for 64 hours. The mixture then was filtered and the product washed with hot ethanol to yield the title compound (0.610 g, 61%); identical (ir, nmr) with authentic material prepared according to the procedure of J. Med. Chem., 18, 224 (1975)).
후처리
- temperaturewas heated
- temperatureat reflux for 64 hours
- filtrationThe mixture then was filtered
- washthe product washed with hot ethanol
출처 및 근거
- ORD 기록
- ord-010268cdc6104f87b6776ca4b1bce98c
- 출처 데이터셋
- uspto-grants-1980_06
- 특허 번호
- US04208521
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