Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Fluorouracil → Tegafur
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Fluorouracil | HCID 3385 | — |
| 반응물 | Hexamethyldisilazane | HCID 13838 | — |
| 반응물 | Tin tetrachloride | HCID 24287 | — |
| 반응물 | Tetrahydro-2-methoxyfuran | HCID 47519 | — |
| 반응물 | Tetrahydro-2-furyl acetate | HCID 102657 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Tegafur | HCID 5386 | 87% |
반응 단계
0.65 g. (5 mmol) of 5-fluorouracil was agitated in 50 ml. of absolute ethylene chloride for one hour with 0.65 g. (4 mmol) of HMDS, 0.43 g. (4 mmol) of TCS, and 1.56 g. (6 mmol) of SnCl4 ; then 0.65 g. (5 mmol) of 2-acetoxytetrahydrofuran or 0.51 g. (5 mmol) of 2-methoxytetrahydrofuran was added to the mixture, and the latter was agitated for 2 hours and 4 hours, respectively, at 24° C. The mixture was worked up as described in Example 1, giving in an 87% yield N1 -(2-tetrahydrofuryl)-5-fluorouracil, m.p. 165°-167° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04209613 |
| 출처 데이터셋 | uspto-grants-1980_06 |
| ORD ID | ord-9070a9e3beac4190a465513a1d707e4b |
| 출처 메모 | uspto-grants-1980_06 |