Ammonia → Ethyl 1-(aminomethyl)cyclopentanecarboxylate

HRID 1707417노트

반응식

HRID 1707417 반응식
[C:1]([C:3]1([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1)#[N:2].N>C(O)C.[Rh]>[NH2:2][CH2:1][C:3]1([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 15688760Ethyl 1-cyanocyclopentane-1-carboxylate

생성물 1

HCID 21840386Ethyl 1-(aminomethyl)cyclopentanecarboxylate

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 702Ethanol용매

실험 절차

20 g of ethyl 1-cyanocyclopentanecarboxylate are placed in 200 ml of a 10% solution of ammonia in ethanol and hydrogenated at 60° C. under a pressure of 100 bar in the presence of rhodium-on-alumina for 72 hours. After filtration on cellite®--and evaporation, the residue is chromatographed on silica using a DCM/methanol/20% aqueous ammonia mixture (98/2/0.5; v/v/v) as the eluent.

후처리

  1. filtrationAfter filtration on cellite®
  2. customevaporation
  3. customthe residue is chromatographed on silica using a DCM/methanol/20% aqueous ammonia mixture (98/2/0.5

출처 및 근거

ORD 기록
ord-d1e1295e4b4a44718cda561d4fb4d0f8
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05352788

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