Piperazin-1-yl-pyridin-4-yl-methanone → HCID 15224911, 화합물

HRID 1707632노트

반응식

HRID 1707632 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[N:20]1[CH:25]=[CH:24][C:23]([C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:27])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:31]3[CH2:32][CH2:33][N:28]([C:26]([C:23]4[CH:24]=[CH:25][N:20]=[CH:21][CH:22]=4)=[O:27])[CH2:29][CH2:30]3)=[O:12])[C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 876553Piperazin-1-yl-pyridin-4-yl-methanoneHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

생성물 1

HCID 15224911HCID 15224911, 화합물수율 21%

실험 절차

The title compound of Example 2 (0.51 g, 1.7 mmol) was reacted with the title product of Example 27 (0.33 g, 1.7 mmol) by the method of Example 4. Following chromatographic purification, 0.16 g of the title product was obtained.

후처리

  1. custompurification

출처 및 근거

ORD 기록
ord-f35ea4cf608a443b84a5beec4fa1645d
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05354747

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