Phosgene → 8-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

HRID 1707650노트

반응식

HRID 1707650 반응식
[C:1]([Cl:4])(Cl)=[O:2].[Cl:5][C:6]1[CH:20]=[CH:19][C:9]2[S:10][C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][NH:14][C:8]=2[CH:7]=1.C(N(CC)CC)C>O1CCCC1>[Cl:5][C:6]1[CH:20]=[CH:19][C:9]2[S:10][C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]([C:1]([Cl:4])=[O:2])[C:8]=2[CH:7]=1

참가 물질

5

반응물 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 542201108-Chloro-10,11-dihydrodibenzo[b,f][1,4]thiazepine

생성물 1

HCID 229217168-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a cold (ice-H2O bath), stirred solution of phosgene (1.93M in toluene; 8.6 mL) in anhydrous tetrahydrofuran (40 mL) under a nitrogen atmosphere is added, dropwise, a solution of the product of Example 104 (8-chloro-10,11-dihydrodibenzo[b,f][1,4]thiazepine) (2.00 g) and triethylamine (1.3 mL) in anhydrous tetrahydrofuran (30 mL). The resulting mixture is stirred at room temperature for 90 minutes, and the solvent is then evaporated in vacuo to provide the title product.

후처리

  1. additionis added
  2. customthe solvent is then evaporated in vacuo

출처 및 근거

ORD 기록
ord-a7791d8f8ad94dac93a51d96ca426dcc
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05354747

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