1-(2-Furylmethyl)piperazine → 1-[(8-chlorodibenz[b,f][1,4]thiazepin-10(11H)-yl)carbonyl]-4-(2-furanylmethyl)piperazine

HRID 1707651노트

반응식

HRID 1707651 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[CH2:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:29]3[CH2:30][CH2:31][N:26]([CH2:25][C:21]4[O:20][CH:24]=[CH:23][CH:22]=4)[CH2:27][CH2:28]3)=[O:12])[C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 7647161-(2-Furylmethyl)piperazineHCID 229217168-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

생성물 1

HCID 193775931-[(8-chlorodibenz[b,f][1,4]thiazepin-10(11H)-yl)carbonyl]-4-(2-furanylmethyl)piperazine

실험 절차

The title compound of Example 105 is reacted with the product of Example 63 by the method of Example 4. Following chromatographic separation, the title product is obtained.

후처리

  1. customseparation

출처 및 근거

ORD 기록
ord-899a5c396a184dcd84a591934c9360d2
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05354747

반응 노트

불러오는 중…