Benzoic Acid → 12-(Methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal

HRID 1707785

반응식

HRID 1707785 반응식
[CH3:1][C:2](O)([CH2:5][CH2:6][CH:7]=[C:8]([CH3:19])[CH2:9][CH2:10][CH:11]=[C:12]([CH3:18])[CH2:13][O:14][CH2:15][O:16][CH3:17])[C:3]#[CH:4].C(O)(=[O:28])C1C=CC=CC=1>C1(C)C(C)=CC=CC=1>[CH3:17][O:16][CH2:15][O:14][CH2:13][C:12]([CH3:18])=[CH:11][CH2:10][CH2:9][C:8]([CH3:19])=[CH:7][CH2:6][CH2:5][C:2]([CH3:1])=[CH:3][CH:4]=[O:28]

참가 물질

4

반응물 2

HCID 243Benzoic AcidHCID 1317181583,7,11-Trimethyl-12-(methoxymethyl)oxy-6,10-dodecadien-1-in-3-ol

생성물 1

HCID 5720638812-(Methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal수율 506.2%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of 3,7,11-trimethyl-12-(methoxymethyl) oxy-6,10-dodecadien-1-in-3-ol (175 mg, 0.62 mmol), tris (triphenylsilyl)vanadate (49 mg, 0.062 mmol), and benzoic acid (7.6 mg, 0.062 mmol) in xylene (2 ml) was stirred on an oil bath at 140° C. After two-hour-stirring, the solution was allowed to cool to room temperature and concentrated. The resultant residue was subjected to silica gel column chromatography to obtain 12-(methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (88 mg, 50%).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-22473f9c90b34337816051993991042f
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05354874

연결된 노트

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