Ammonia → 6-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

HRID 1708146노트

반응식

HRID 1708146 반응식
[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12]([O:14]C)=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[NH3:16]>C(O)C>[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12](=[O:14])[NH2:16])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 152251016-Butyl-4-methoxycarbonyl-2-oxo-1,2-dihydropyridine

생성물 1

HCID 189608186-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3 g (14.3mmol) of the compound from Example 1 are heated for a few minutes in 10 ml of ethanol and 20 ml of conc. ammonia. A further 5 ml of conc. ammonia are then added three times each and the mixture is again briefly heated to boiling. After cooling, the precipitate is filtered off with suction and dried over P2O5 in vacuo.

후처리

  1. temperatureis again briefly heated to boiling
  2. temperatureAfter cooling
  3. filtrationthe precipitate is filtered off with suction
  4. dry with materialdried over P2O5 in vacuo

출처 및 근거

ORD 기록
ord-62b55189dfa94ea3981f2520f962ecf7
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05356911

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