HCID 14835675, 화합물 → HCID 14835676, 화합물

반응식

[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([NH:9][NH2:10])=[O:8].[CH:16]([O-])([O-])OC>>[CH3:15][O:14][CH:3]([O:2][CH3:1])[C:4]1[CH:5]=[C:6]([C:7]2[O:8][CH:16]=[N:10][N:9]=2)[CH:11]=[CH:12][CH:13]=1

참가 물질

반응물 2

HCID 14835675HCID 14835675, 화합물

HCID 53629101Methylorthoformate

생성물 1

HCID 14835676HCID 14835676, 화합물수율 61.4%

실험 절차

2.1 g of 3-dimethoxymethylbenzhydrazide and 12.7 g of methyl orthoformate were reacted at atmospheric pressure for 24 hours while distilling off the methanol formed. Excessive methyl orthoformate was removed by distillation under reduced pressure. The residue was purified by a column chromatography (eluant: n-hexane/ethyl acetate=3/1) to obtain 1.35 g of colorless oily 2-(3-dimethoxymethylphenyl)-1,3,4-oxadiazole.

후처리

distillationwhile distilling off the methanol
customformed
customExcessive methyl orthoformate was removed by distillation under reduced pressure
customThe residue was purified by a column chromatography (eluant: n-hexane/ethyl acetate=3/1)

출처 및 근거

ORD 기록: ord-4d560382b83a44feb0a329157b3c91ab
출처 데이터셋: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04948796

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