Potassium Hydroxide → 6-Nitro-2,5-pyridinediamine

반응식

C(OC([NH:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(OCC)=O)=[C:9]([N+:19]([O-:21])=[O:20])[N:8]=1)=O)C.[OH-].[K+]>>[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([N+:19]([O-:21])=[O:20])[N:8]=1

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 14366181HCID 14366181, 화합물

생성물 1

HCID 98152436-Nitro-2,5-pyridinediamine

실험 절차

4.0 g of the biscarbamate of Example 9 are boiled in 200 ml of an ethanolic 3 percent potassium hydroxide solution for 18 hours with reflux. This is followed by filtering and the filtrate is acidified with concentrated sulphuric acid, whereupon it is concentrated in vacuo. The residue is taken up in methanol. The desired product then crystallizes as hydrochloride (melting point 241° C.).

후처리

temperaturewith reflux
filtrationby filtering
concentrationis concentrated in vacuo
customThe desired product then crystallizes as hydrochloride (melting point 241° C.)

출처 및 근거

ORD 기록: ord-4764633e04894bfd9aa008fa8af608f2
출처 데이터셋: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04950302

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