Ethylene Glycol → Polyethylene glycol monocaprylate

HRID 1709720

반응식

HRID 1709720 반응식
[C:1]([OH:10])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH2:11](O)[CH2:12][OH:13]>>[C:1]([O:10][CH2:11][CH2:12][OH:13])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

3

반응물 2

HCID 174Ethylene GlycolHCID 379Octanoic Acid

생성물 1

HCID 170609Polyethylene glycol monocaprylate

실험 절차

Anhydride of caprylic acid (0.477 mol; 129 g) was dropwise added into boiling dry ethylene glycol (3.16 mol; 196 g) and the mixture was refluxed for further 4 hours. The mixture was cooled, extracted twice with benzene (100+20 ml), benzene was evaporated in a rotation evaporator, and the residue was distilled. 2-Hydroxyethyl caprylate was obtained in the yield of 142.75 g (159% of theory), which is the evidence that almost 2/3 of caprylic acid formed was esterified with glycol under the experimental conditions. The raw fractions had purity 88.9 to 97.5% of 2-hydroxyethyl caprylate. Further procedure was carried out according to example 1.

후처리

  1. temperaturethe mixture was refluxed for further 4 hours
  2. temperatureThe mixture was cooled
  3. extractionextracted twice with benzene (100+20 ml), benzene
  4. customwas evaporated in a rotation evaporator
  5. distillationthe residue was distilled

출처 및 근거

ORD 기록
ord-d704a49c1ae44f66bd6a9553e55e7bf7
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04950733

연결된 노트

불러오는 중…