Water → 4,5,5-Trifluoro-4-penten-1-ol

HRID 1710014노트

반응식

HRID 1710014 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8](=[C:14]([F:16])[F:15])[CH2:9][CH2:10][C:11](O)=[O:12].O>C(OCC)C>[F:7][C:8](=[C:14]([F:16])[F:15])[CH2:9][CH2:10][CH2:11][OH:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 27824474,5,5-trifluoropent-4-enoic AcidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 27779334,5,5-Trifluoro-4-penten-1-ol수율 57.1%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a stirred suspension of 0.4 gram (0.01 mole) of lithium aluminum hydride in 20 ml of diethyl ether was added dropwise a solution of 1.5 grams (0.01 mole) of 4,5,5-trifluoro-4-pentenoic acid in 30 ml of diethyl ether. Upon completion of addition the reaction mixture was stirred at ambient temperature for one hour, then 20 ml of water was added carefully. The mixture was filtered and the filtrate concentrated under reduced pressure to give 0.8 gram of 4,5,5-trifluoro-4-penten-1-ol as an oil. The nmr and the ir spectra were consistent with the proposed structure.

후처리

  1. additionUpon completion of addition the reaction mixture
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-55f5c6633b8841daaa2ef5f0a3761a9c
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04952580

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