Ammonia → 2,6-Difluoro-4-(trifluoromethyl)aniline
반응식
[F:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([F:9])[C:7]=1F.[NH3:14]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([F:9])[C:7]=1[NH2:14]참가 물질
4
실험 절차
In a stainless steel autoclave, 500 g of 3,4,5-trifluoro-benzotrifluoride are introduced, 2,000 ml of tetrahydrofuran are added, and 150 g of liquid ammonia are forced in. The autoclave is heated to 120° to 130° C. for 5 hours with stirring, then cooled, and the pressure is released at 20° C. In addition to the solvent and the starting material, 272 g of 3,5-difluoro-4-amino-benzotrifluoride of a boiling point of 58° to 60° C. at 16 mbar are obtained by distillation.
후처리
- temperatureThe autoclave is heated to 120° to 130° C. for 5 hours
- temperaturecooled
- customis released at 20° C
- additionIn addition to the solvent
출처 및 근거
- ORD 기록
- ord-e62aea368a30456287064e43b2c16f6c
- 출처 데이터셋
- uspto-grants-1990_08
- 특허 번호
- US04952601
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