HCID 86744189, 화합물 → Pirazolac

HRID 1710200노트

반응식

HRID 1710200 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([O-:23])=[O:22])=[N:9]2)=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([OH:23])=[O:22])=[N:9]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 86744189HCID 86744189, 화합물

생성물 1

HCID 51222Pirazolac

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

1,49 Grams (3 mM) of the benzohydryl [1-(4-fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazol-3-yl]-acetate are dissolved in 40 ml of tetrahydroflurane. To the solution 0,4 g of Pd on charcoal (10%) are added, then the mixture is hydrogenated at room temperature and pressure. At the end of the reaction the catalysator is filtered, the solvent evaporated and the product crystallized from acetic acid/ethanol. The title product is obtained in almost quantitative yield.

후처리

  1. customis hydrogenated at room temperature
  2. customAt the end of the reaction the catalysator
  3. filtrationis filtered
  4. customthe solvent evaporated
  5. customthe product crystallized from acetic acid/ethanol

출처 및 근거

ORD 기록
ord-f2ab52f269b44a928d2852f75c3558b9
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04952702

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