Hydrofluoric Acid → 2-(4-Methylphenyl)-2-phenylhexafluoropropane

HRID 1710207

반응식

HRID 1710207 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](O)([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.F>C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14917Hydrofluoric Acid2회HCID 748292-(p-Tolyl)hexafluoroisopropanol

생성물 1

HCID 147667062-(4-Methylphenyl)-2-phenylhexafluoropropane

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

1290 g of 2-(4-methylphenyl)hexafluoropropan-2-ol and 780 g of benzene were placed in a 5-liter steel autoclave and 1500 g of anhydrous hydrogen fluoride was pumped into the sealed autoclave. The reaction mixture was heated at 170°-175°C. with stirring for 64 hours. After completion of the reaction, hydrogen fluoride gas was allowed to escape at 80° C., and the liquid product was then washed twice with water, dried over calcium chloride, and fractionally distilled. Boiling point 135-136C./1.4 mbar. Yield: 1424 g (89.5%).

후처리

  1. temperatureThe reaction mixture was heated at 170°-175°C.
  2. customto escape at 80° C.
  3. washthe liquid product was then washed twice with water
  4. dry with materialdried over calcium chloride
  5. distillationfractionally distilled

출처 및 근거

ORD 기록
ord-851e4c46fbec456790ceb849b70d397e
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04952669

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