2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-2-oxoacetic acid 2,2,2-trichloroethyl ester → (3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidine
반응식
ClC(Cl)(Cl)COC(=O)C([N:8]1[C@H:11]([S:12][C:13](=[O:15])[CH3:14])[C@@H:10]([O:16][CH3:17])[C:9]1=[O:18])=O>CO.C(OC)(=O)C.O>[C:13]([S:12][C@H:11]1[NH:8][C:9](=[O:18])[C@@H:10]1[O:16][CH3:17])(=[O:15])[CH3:14]참가 물질
5
실험 절차
A solution of 1.52 g of 2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-2-oxoacetic acid 2,2,2-trichloroethyl ester (crude product) in 290 ml of methanol, 40 ml of methyl acetate and 5.9 ml of water is refluxed for 20 minutes under nitrogen. The solvent is evaporated off in vacuo. After chromatography over silica gel with toluene/ethyl acetate (3:1) the residue yields the title compound.
후처리
- customThe solvent is evaporated off in vacuo
출처 및 근거
- ORD 기록
- ord-9efb43ac130a4fb7a800ec706c2cd1ce
- 출처 데이터셋
- uspto-grants-1990_08
- 특허 번호
- US04952690
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