Ammonia → HCID 59457468, 화합물

HRID 1710775노트

반응식

[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](Cl)=[O:11])=[C:8]([F:15])[CH:7]=1.[NH3:16]>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:16])=[O:11])=[C:8]([F:15])[CH:7]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 59457513HCID 59457513, 화합물

생성물 1

HCID 59457468HCID 59457468, 화합물수율 61%

실험 절차

4-(3-chloropropoxy)-2-fluorobenzoyl chloride i80 (0.73 g, 2.91 mmol, 1 eq) is treated with aqueous ammonia (35 ml) and the resulting mixture is vigorously stirred at room temperature overnight. The mixture is then filtered to give 0.41 g of 4-(3-chloropropoxy)-2-fluorobenzamide i82 as a white solid.

후처리

filtrationThe mixture is then filtered

출처 및 근거

ORD 기록: ord-adc5803454b446bb9e09f6f69ceee70f
출처 데이터셋: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07790720B2

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