(3-hydroxyphenyl)boronic Acid → 3-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenol
반응식
[F:1][C:2]1[CH:24]=[C:23]([N+:25]([O-:27])=[O:26])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12](C3C=CC(O)=CC=3)[S:13][C:6]=12.[OH:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1>>[F:1][C:2]1[CH:24]=[C:23]([N+:25]([O-:27])=[O:26])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:33]3[CH:34]=[C:29]([OH:28])[CH:30]=[CH:31][CH:32]=3)[S:13][C:6]=12참가 물질
3
실험 절차
Starting from the nitrobromo compound 42, following the procedure described above for the synthesis of compound 153 (scheme 28, example 109) but substituting 4-hydroxyphenylboronic acid for 3-hydroxyphenylboronic acid, title compound 160 was obtained in 66% yield as a gray solid. LRMS (M+1) 383.1 (100%).
출처 및 근거
- ORD 기록
- ord-d4bdbfa1320e4eee82bb49d641714d01
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07790729B2
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