7-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridine → 6-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

HRID 1711046노트

반응식

HRID 1711046 반응식
[Br:1][C:2]1[C:3](Cl)=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[F:12][C:13]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:14]=1[O:15]C1N=CC=C2C=CNC=12>>[Br:1][C:2]1[C:3]([O:15][C:14]2[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:13]=2[F:12])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 594246417-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridineHCID 594246556-Bromo-7-chlorothieno(3,2-b)pyridine

생성물 1

HCID 594244576-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine수율 61%

실험 절차

Starting from the compound 271 and following the procedure described above for the synthesis of compound 260 (scheme 59, example 218, step 2), title compound 272 was obtained in 61% yield as an off-white solid. MS (m/z): 368.9 (M+H).

출처 및 근거

ORD 기록
ord-ae19a326e025406fbb57d2235377f516
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790729B2

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